Cardiovascular risk associated with the use of Non-Steroidal Anti-inflammatory Drugs (NSAID)
Keywords:
COX-2 selective Inhibitor, risk cardiovascularAbstract
Objective: This research's general objective is to analyze the articles presented on cardiovascular risk with the use of NSAIDs.
Material and Methods: This literature review was carried out manually, using platforms such as "PubMed", "Scielo", and "Danish International Research Database". As inclusion criteria, the bibliography comprised in the last five years was considered, in which there were systematic reviews, reviews, meta-analyses, clinical trials, and randomized controlled trials. As exclusion criteria, it was considered to rule out studies applied in animals, presentations of clinical cases, studies that dealt with the use of NSAIDs associated with other pharmacological treatments, studies that considered only one specific NSAID.
Results: The search strategy generated 41 potentially relevant studies. The titles and abstracts of the studies found were examined, applying the inclusion and exclusion criteria, leaving a total of 18 articles for detailed evaluation.
Conclusion: Due to NSAIDs' cardiovascular risk, it is of real importance to take into account the patient's cardiovascular status before prescribing the drug. It is recommended not to administer for long periods to patients with underlying cardiovascular diseases or people with cardiovascular risk factors.
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