Hyperbaric oxygen therapy in the management of osteonecrosis associated with bisphosphonates: a bibliographic review
DOI:
https://doi.org/10.22370/asd.2020.1.0.2630Keywords:
Hyperbaric oxygenation, bisphosphonates, osteonecrosisAbstract
Objective: To evaluate the benefits of the use of hyperbaric oxygen therapy in patients treated with bisphosphonates suffering from osteonecrosis.
Material and Methods: A search was carried out in Medline metasearch engines, Cochrane Library, and Embase using the Mesh terms " Hyperbaric Oxygenation " AND "Biphosphonates" OR "Osteonecrosis". Inclusion criteria were studies performed in humans, in English, and with a maximum of 5 years of antiquity. Animal studies were excluded.
Results: Of a total of 21 articles, 12 were included, of which 7 were systematic reviews, 4 literature reviews, and 1 case report. A beneficial effect of the use of HOT as a complementary treatment to the management of osteonecrosis was mostly observed in patients with bisphosphonate treatment.
Conclusion: Hyperbaric oxygen therapy in the management of bisphosphonate-associated osteonecrosis showed promising results by counteracting the effects of osteonecrosis, being a complementary measure to other conventional treatments. However, better and more evidence is needed to support these results.
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